Jan Nolta Lab in the UC Davis Medical Center
Institute for Regenerative Cures - 2016
The UC Davis Stem Cell Program, directed by Dr. Jan Nolta, is housed in the Institute for Regenerative Cures (IRC) in Sacramento, CA. This Institute was renovated from a 109,000 square-foot State Fair building in 2008 with funding from a major facilities grant from the California Institute for Regenerative Medicine (CIRM).
The IRC opened in March 2010 and is the hub for for stem cell and regenerative medicine research and clinical trials for investigators on the Sacramento (UCDHS) and Davis campuses, and collaborators. It houses over 200 faculty, basic and clinical scientists, veterinarians, researchers, staff members, students, volunteers and trainees. UC Davis is playing a leading role in regenerative medicine, with over 150 faculty members working together in teams focused on turning stem cells into cures.
UC Davis has ten ongoing or recently completed stem cell and regenerative medicine clinical trials, with another 20 in the pipeline.
Our Program Brochure is linked here.
Our Program Website through the University is linked here.
The IRC also performs IND-enabling studies and clinical trials with many academic and industry partners outside of UC Davis. The UC Davis Stem Cell program, directed by Dr. Jan Nolta and housed within the IRC, has everything that partners need for their IND-enabling studies, with approved rates: a state-of-the art 6 suite Good Manufacturing Practices Facility, a shower in barrier humanized mouse facility for safety and efficacy testing of cell and gene therapy products, a vector core, karyotyping core, Stem Cell core, Quality control and quality assurance core, teratoma core, umbilical cord blood collections program, and a regulatory team. Staff members have extensive experience in stem cell and gene therapy clinical trials.
Our fee-for-service brochure is linked here.
We are working with Foundations and individual Philanthropists who are interested in developing therapies for rare diseases about which they are passionate. Dr. Nolta and Fink's work on HD and JHD are great examples (please see the following pages). We are always happy to discuss new or ongoing avenues of research.
All donations of any size are greatly appeciated, to help our young scientists. They have amazing new ideas!
To make a tax-free donation online please choose "stem cell program" from the drop-down menu at:
And write in the team, individual or area of choice to be supported, in the box, “Special instructions for this gift”
2016 -Welcome to the Shared Translational Stem Cell Program Lab at the University Of California, Davis Medical Center Campus in Sacramento, Institute for Regenerative Cures Building
Happy New Year from our Shared Translational Laboratory! May 2016 be the year of cures.
This picture is of all of us who work together in the bench-to-bedside laboratory, cleanroom mouse vivarium, and Good Manufacturing Practices facility for cell and gene therapy in our Institute for Regenerative Cures building at UC Davis. It is a lab/work family, with some of us having worked together for 25 years now. We help one another and share ideas at our big group meeting every Monday AM, and then continue to share and work together throughout the week (and weekend).
We are working extremely hard to make a difference for families affected by Huntington's disease (HD), juvenile HD, and other rare diseases. We work closely with the physicians who will deliver the therapies and with amazing HD/JHD patient advocates, and advocates for other rare diseases like San Filippo’s and Tay Sachs.
There is strength in numbers and we have strong, brilliant people in our labs. I am so grateful to each of them for their hard work, long hours, and dedication. Together-scientists, physicians, advocates, families, we will make a difference.
Nolta Lab focus:
2012 - CIRM announces funding for disease team therapy research grants, 3 of the four top scores in the state belonging to UC Davis!
CIRM press release:
Listen to KQED Forum Interview with Jan Nolta and Alan Trounson - July 27, 2012 (60 minutes)
Our laboratory works in translational biology at the GLP, or “good laboratory practice” level, required to take stem cell therapies, gene therapy and tissue repair studies from the bench to the bedside.
Dr. Nolta is Director of the UC Davis Stem Cell Program and Scientific Director of the GMP facility and assists other Principal Investigators with the rules and regulations involved with obtaining approvals from the Recombinant advisory committee (RAC) and the FDA for cellular therapies. She works closely with Dr. Gerhard Bauer, the Director of the Good Manufacturing Practice Facility in the UC Davis Institute for Regenerative Cures.
Basic/translational work in our lab centers around developing stem cell therapies for peripheral vascular disease and other ischemic disorders, and using stem cells to treat neurodegenerative disorders, primarily focusing on Huntington's Disease (HD/ JHD).